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PolyPeptide Laboratories
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Tocris
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Millipore
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Journal: Communications Medicine
Article Title: Preclinical characterization of an active immunotherapy targeting calcitonin gene-related peptide
doi: 10.1038/s43856-025-00870-2
Figure Lengend Snippet: a Sequence alignment of the 37mer signaling peptide, CGRP. Conserved residues represented by *. Red box indicates the targeting peptide sequence (B cell epitope) of the human αCGRP peptide immunogen, p4796kb, and the rat αCGRP peptide immunogen, p5830kb. Anti-CGRP antibody titers over time in rat ( n = 5) ( b ), guinea pig ( n = 3) ( c ), and NHP ( n = 3) ( d ). Anti-human αCGRP (K35K) ( e ) and anti-rat αCGRP (K35E) ( f ) IgG titers in sera collected post-immunization in rats injected with p4796kb or p5380kb ( n = 5 per group). g Serum concentrations (μg/mL) of anti-CGRP antibodies. Red arrowheads indicate dosing time points. Individual data points are presented on each graph.
Article Snippet: Microtiter 96-well plates were 1st coated with 100 μL of 2 μg/mL of the full-length synthetic human or
Techniques: Sequencing, Injection